Description

3-Pyridine-D4-Acetic Acid is a deuterated isotopologue of nicotinic acid, where four hydrogen atoms are replaced with deuterium. This high-purity labeled compound is essential for advanced research and development, providing a stable internal standard for precise analytical quantification. It is primarily utilized by scientists and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for applications in drug metabolism studies, mass spectrometry, and NMR spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical reference compound in quantitative LC-MS and GC-MS analysis for accurate measurement of nicotinic acid and related metabolites.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in the synthesis of deuterated drug candidates and metabolites to study absorption, distribution, metabolism, and excretion (ADME) pathways.
• NMR Spectroscopy Solvent & Reagent: Acts as a deuterated solvent or reagent in nuclear magnetic resonance studies to eliminate interfering proton signals.
• Pharmaceutical Intermediate: A key building block in the research and development of novel pharmaceutical compounds requiring isotopic labeling.
• Agrochemical Research: Employed in the development and analysis of labeled pesticides or plant growth regulators.
• Analytical Reference Standard: Provides a certified reference material for method validation and quality control in analytical laboratories.

Basic Information

Product Name	3-Pyridine-D4-Acetic Acid
CAS No.	1035439-74-7
Molecular Formula	C7D4H3NO2
Molecular Weight	127.13 g/mol (deuterated form)
Synonyms	Deuterated Nicotinic Acid; Nicotinic Acid-d4; Pyridine-3-carboxylic Acid-d4; 3-Carboxypyridine-d4; Vitamin B3-d4; Niacin-d4; 3-Pyridinecarboxylic Acid-d4; 3-Picolinic Acid-d4
EINECS	Contact for details

Quality Control

Our 3-Pyridine-D4-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure high isotopic purity and chemical purity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.