Description

5-[(tert-Butoxycarbonyl)Amino]Bicyclo[3.1.1]Heptane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique bicyclo[3.1.1]heptane scaffold. This compound is a critical building block in medicinal chemistry, valued for its role in introducing constrained, three-dimensional geometry into target molecules. It is primarily utilized by research and development organizations and contract manufacturing organizations (CMOs) in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas like central nervous system (CNS) and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting G-protein-coupled receptors (GPCRs).
• Peptidomimetics & PROTACs: Serves as a rigid, non-natural amino acid analog in the design of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) to modulate protein degradation.
• Medicinal Chemistry Research: Used in lead optimization to improve the metabolic stability, potency, and selectivity of preclinical compounds by incorporating a sterically defined bicyclic structure.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CMOs engaged in custom synthesis and process development for client-specific molecules.

Basic Information

Product Name	5-[(tert-Butoxycarbonyl)Amino]Bicyclo[3.1.1]Heptane-1-Carboxylic Acid
CAS No.	1035325-28-0
Molecular Formula	C₁₄H₂₃NO₄
Molecular Weight	269.34 g/mol
Synonyms	1-Boc-3-azabicyclo[3.1.1]heptane-3-carboxylic acid; 5-[(tert-Butoxycarbonyl)amino]bicyclo[3.1.1]heptane-1-carboxylic acid; 5-(Boc-amino)bicyclo[3.1.1]heptane-1-carboxylic acid; 3-Azabicyclo[3.1.1]heptane-1-carboxylic acid, 1-(1,1-dimethylethyl) ester; Bicyclo[3.1.1]heptane-1-carboxylic acid, 5-[(1,1-dimethylethoxy)carbonyl]amino]-; tert-Butyl 3-azabicyclo[3.1.1]heptane-3-carboxylate-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-[(tert-Butoxycarbonyl)Amino]Bicyclo[3.1.1]Heptane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.