Description

Iloprost-D4 (Major) is a high-purity, deuterium-labeled analog of the stable prostacyclin analog Iloprost, specifically designed for use as an internal standard in quantitative bioanalytical studies. This compound is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic research by correcting for variations in sample preparation and instrument analysis. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on cardiovascular and pulmonary drug development, where precise measurement of Iloprost is required.

Application

• Primary use as an Internal Standard (IS) in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of Iloprost in biological matrices (plasma, serum, tissue).
• Supporting Pharmacokinetic (PK) and Bioavailability Studies for drug formulations containing Iloprost or related analogs.
• Enabling Metabolite Identification and Profiling studies in drug metabolism and disposition (DMPK) research.
• Use in Stable Isotope Dilution Assays (SIDA) to achieve high-precision analytical results in clinical and preclinical research.
• Quality control and method validation in Good Laboratory Practice (GLP) and GMP-compliant analytical laboratories.

Basic Information

Product Name	Iloprost-D4 (Major)
CAS No.	1035094-10-0
Molecular Formula	C₂₂H₃₂D₄O₄
Molecular Weight	368.53 g/mol
Synonyms	5-[(3aR,4R,5R,6aS)-5-Hydroxy-4-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]hexahydro-2H-cyclopenta[b]furan-2-yl]-3-oxapentanoic Acid-d4; (Z)-5-[(1R,2R,3R,5S)-3-Hydroxy-2-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-oxocyclopentyl]-3-oxapentanoic Acid-d4; Iloprost-d4; Deuterated Iloprost; Iloprost Internal Standard; ZK 36374-d4
EINECS	Contact for details

Quality Control

Our Iloprost-D4 (Major) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, isotopic enrichment, and solvent content, supporting its use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.