Description

Erlotinib D6 is a deuterated isotopologue of the tyrosine kinase inhibitor Erlotinib, specifically labeled with six deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise quantification of Erlotinib in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors, ensuring accurate pharmacokinetic studies, bioanalytical method development, and drug metabolism research.

Application

• Primary use as an internal standard for the quantitative analysis of Erlotinib via Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Critical component in bioanalytical method development and validation for Erlotinib in plasma, serum, and tissue samples.
• Enabling accurate pharmacokinetic (PK) and pharmacodynamic (PD) studies during clinical trials and preclinical research.
• Supporting drug metabolism and disposition (DMPK) investigations to understand the absorption, distribution, metabolism, and excretion of Erlotinib.
• Quality control and assurance in pharmaceutical manufacturing for batch analysis of Erlotinib active pharmaceutical ingredient (API) and finished dosage forms.
• Use in forensic and anti-doping analysis for the definitive identification and quantification of Erlotinib.

Basic Information

Product Name	Erlotinib D6
CAS No.	1034651-23-4
Molecular Formula	C22H17D6N3O4
Molecular Weight	403.48 g/mol
Synonyms	N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine-d6; Tarceva-d6; CP-358774-d6; OSI-774-d6; NSC 718781-d6; Erlotinib (phenyl-d5, ethynyl-d); Erlotinib-d6 (Major); Deuterated Erlotinib
EINECS	Contact for details

Quality Control

Every batch of Erlotinib D6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment (D-content), and identification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with our stringent specifications. Our quality commitment supports applications requiring regulatory submission data.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.