Description

D-Glucitol, 1,5-Anhydro-1-C-[3-(Benzo[B]Thien-2-Ylmethyl)-4-Fluorophenyl]-, 2,3,4,6-Tetraacetate, (1S)- is a sophisticated, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block in the synthesis of novel therapeutic agents, particularly those targeting complex metabolic and signaling pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs) and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of novel drug candidates, particularly in metabolic disease and oncology research.
• Active Pharmaceutical Ingredient (API) Development: Used as a core scaffold or advanced intermediate in the development and scale-up of new chemical entities (NCEs).
• Biochemical Research: Employed in academic and industrial research to study enzyme inhibition, receptor binding, and other structure-activity relationship (SAR) studies.
• Process Chemistry: Serves as a critical material for optimizing synthetic routes, developing robust manufacturing processes, and producing reference standards.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized, high-value compounds under cGMP conditions.

Basic Information

Product Name	D-Glucitol, 1,5-Anhydro-1-C-[3-(Benzo[B]Thien-2-Ylmethyl)-4-Fluorophenyl]-, 2,3,4,6-Tetraacetate, (1S)-
CAS No.	1034305-21-9
Molecular Formula	C29H29FO9S
Molecular Weight	572.60 g/mol
Synonyms	(1S)-1,5-Anhydro-1-C-[3-[(2-Benzothienyl)methyl]-4-fluorophenyl]-D-glucitol 2,3,4,6-tetraacetate; 1,5-Anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-2,3,4,6-tetra-O-acetyl-D-glucitol; (1S)-1,5-Anhydro-1-C-[3-(2-Benzothienylmethyl)-4-fluorophenyl]-2,3,4,6-tetra-O-acetyl-D-glucitol; SGLT2 Inhibitor Intermediate; Canagliflozin Advanced Intermediate; Canagliflozin Tetraacetate Derivative; (1S)-Canagliflozin Tetraacetate Precursor
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. We provide full traceability and detailed Certificates of Analysis (COA) to support regulatory filings (e.g., DMF, CMC sections) and ensure compliance with cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (1S-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.