Description

(R)-1-(2-Bromo-4-Chlorophenyl)-2,2,2-Trifluoroethanol is a high-value chiral building block and key pharmaceutical intermediate. Its significance lies in its trifluoromethyl and halogenated aromatic structure, which is crucial for imparting desirable metabolic stability and lipophilicity to target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals due to its unique fluorinated aromatic properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	(R)-1-(2-Bromo-4-Chlorophenyl)-2,2,2-Trifluoroethanol
CAS No.	1033805-25-2
Molecular Formula	C8H5BrClF3O
Molecular Weight	289.48 g/mol
Synonyms	(R)-2-Bromo-4-chloro-α-(trifluoromethyl)benzyl alcohol; (R)-1-(2-Bromo-4-chlorophenyl)-2,2,2-trifluoroethan-1-ol; (R)-α-(Trifluoromethyl)-2-bromo-4-chlorobenzyl alcohol; (R)-2,2,2-Trifluoro-1-(2-bromo-4-chlorophenyl)ethanol; (R)-1-(2-Bromo-4-chloro-phenyl)-2,2,2-trifluoro-ethanol; (R)-TFBCOBrCl; (R)-enantiomer of 1-(2-Bromo-4-chlorophenyl)-2,2,2-trifluoroethanol
EINECS	Contact for details

Quality Control

Our (R)-1-(2-Bromo-4-Chlorophenyl)-2,2,2-Trifluoroethanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with exacting R&D and cGMP standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.