Description

2-[2-(4-Benzo[B][1,4]Benzothiazepin-6-Ylpiperazin-1-Yl)-1,1,2,2-Tetradeuterioethoxy]-1,1,2,2-Tetradeuterioethanol is a deuterated derivative of a benzothiazepine-piperazine compound, serving as a critical stable isotope-labeled intermediate. This high-purity compound is essential for advanced research and development, particularly in the fields of pharmacology and analytical chemistry. It is primarily utilized by pharmaceutical R&D teams and contract research organizations (CROs) for use as an internal standard in mass spectrometry, metabolic studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS for the quantitative analysis of drug candidates and their metabolites.
• Metabolic Pathway Studies: Enables precise tracking and identification of metabolic products in in vitro and in vivo studies due to its deuterium labeling.
• Drug Discovery: Serves as a key building block or reference compound in the synthesis and screening of new benzothiazepine-based therapeutics.
• Bioanalytical Method Development: Critical for developing and validating highly sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Isotope Dilution Mass Spectrometry (IDMS): Provides the accuracy and precision required for definitive quantitative analysis in clinical and forensic toxicology.
• Chemical Reference Standard: Used for quality control and calibration in laboratories to ensure the accuracy of analytical results.

Basic Information

Item	Detail
Product Name	2-[2-(4-Benzo[B][1,4]Benzothiazepin-6-Ylpiperazin-1-Yl)-1,1,2,2-Tetradeuterioethoxy]-1,1,2,2-Tetradeuterioethanol
CAS No.	1031703-36-2
Molecular Formula	C21H22D4N4O2S
Molecular Weight	~394.55 g/mol (for deuterated form)
Synonyms	Deuterated Benzothiazepine-Piperazine Ethanol Derivative; 1,1,2,2-Tetradeuterio-2-[2-(4-(Benzo[b][1,4]benzothiazepin-6-yl)piperazin-1-yl)-1,1,2,2-tetradeuterioethoxy]ethanol; 6-[4-[2-(1,1,2,2-Tetradeuterio-2-hydroxy-1,1,2,2-tetradeuterioethoxy)ethyl]piperazin-1-yl]benzo[b][1,4]benzothiazepine; Deuterated Internal Standard for Benzothiazepines; D4-Labeled Benzothiazepine Metabolite Standard; 1031703-36-2 (CAS Index Name); BTTE-d4 (Abbreviation)
EINECS	Contact for details

Quality Control

Every batch of our 2-[2-(4-Benzo[B][1,4]Benzothiazepin-6-Ylpiperazin-1-Yl)-1,1,2,2-Tetradeuterioethoxy]-1,1,2,2-Tetradeuterioethanol is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with comprehensive testing performed via NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, isotopic purity (D-enrichment), and solvent content to meet the stringent requirements of research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.