Description

Losartan-D3 is a stable isotope-labeled analog of Losartan, where three hydrogen atoms are replaced by deuterium at specific positions. This high-purity compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development and quality control of antihypertensive medications.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of Losartan and its metabolites in biological matrices like plasma and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of Losartan.
• Clinical Research: Supports bioequivalence and therapeutic drug monitoring studies requiring high-sensitivity analytical methods.
• Pharmaceutical Quality Control: Ensures accuracy in the analysis of active pharmaceutical ingredients (APIs) and finished drug products.
• Reference Material: Serves as a certified reference material (CRM) for method development and validation in analytical laboratories.

Basic Information

Product Name	Losartan-D3
CAS No.	1030936-74-3
Molecular Formula	C22H20D3ClN6O
Molecular Weight	428.96 g/mol
Synonyms	2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol-d3; Losartan (phenyl-d3); [2H3]-Losartan; Losartan-d3; Deuterated Losartan; Cozaar-d3; DuP 753-d3
EINECS	Contact for details

Quality Control

Our Losartan-D3 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for the most demanding analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and confirming identity and absence of critical impurities. We support compliance with cGMP and ISO 17034 standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.