Description

3-(Ethyl-D5)-1,5-Dihydro-4-Methyl-2H-Pyrrol-2-One is a high-purity, deuterated organic compound used as a critical stable isotope-labeled intermediate. This compound matters for its role in enabling advanced analytical techniques, providing essential internal standards for precise quantification in complex matrices. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries for applications in drug metabolism studies, pharmacokinetics, and environmental fate analysis.

Application

• Pharmaceutical Research & Development: As a stable isotope-labeled internal standard for the accurate quantification of metabolites and active pharmaceutical ingredients (APIs) using LC-MS/MS and GC-MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical studies.
• Analytical Chemistry Standards: Serves as a high-purity reference material for method development and validation in mass spectrometry-based assays.
• Agrochemical Research: Used in the study of pesticide and herbicide degradation pathways and environmental residue analysis.
• Biochemical Tracing: Facilitates mechanistic studies in biochemical pathways where the ethyl-D5 moiety provides a non-radioactive tracer.
• Custom Synthesis Intermediate: Acts as a specialized building block for the synthesis of more complex deuterated molecules for research and diagnostic purposes.

Basic Information

Item	Detail
Product Name	3-(Ethyl-D5)-1,5-Dihydro-4-Methyl-2H-Pyrrol-2-One
CAS No.	1028809-94-0
Molecular Formula	C7H6D5NO
Molecular Weight	130.19 g/mol
Synonyms	4-Methyl-3-(ethyl-d5)-1,5-dihydro-2H-pyrrol-2-one; 3-(Ethyl-d5)-4-methyl-1,5-dihydro-2H-pyrrol-2-one; 3-(Pentadeuteroethyl)-4-methyl-2-pyrrolidone; Deuterated 3-Ethyl-4-methyl-2-pyrrolidinone; 3-(C2D5)-4-Methyl-2-pyrrolidone; 1028809-94-0; Ethyl-d5 pyrrolidone derivative
EINECS	Contact for details

Quality Control

Every batch of 3-(Ethyl-D5)-1,5-Dihydro-4-Methyl-2H-Pyrrol-2-One is produced and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting requirements of analytical and synthetic applications. Comprehensive testing includes assay, isotopic enrichment (D-content), and identification by spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.