Description

5-Fluoro-7-Azaindole-3-Carboxylic Acid Methyl Ester is a high-value, heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its fused azaindole scaffold, which serves as a privileged structure for modulating biological activity and physicochemical properties in drug discovery. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular libraries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, particularly for oncology and inflammatory disease targets, where the 7-azaindole core is a common pharmacophore.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Chemical Biology & Probe Development: Employed to create fluorescent probes or affinity tags for studying enzyme function and protein-ligand interactions.
• Material Science Research: Investigated as a monomer or building block for creating organic electronic materials due to its conjugated system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial APIs for clinical trials.
• Academic Research: Utilized in universities and research institutes for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	5-Fluoro-7-Azaindole-3-Carboxylic Acid Methyl Ester
CAS No.	1027530-64-8
Molecular Formula	C9H7FN2O2
Molecular Weight	194.16 g/mol
Synonyms	Methyl 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; 5-Fluoro-7-azaindole-3-methyl carboxylate; 5-F-7-AIA methyl ester; 1027530-64-8; 5-Fluoro-7-aza-indole-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-7-Azaindole-3-Carboxylic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment supports compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.