Description

2,2'-Bis(Ethoxycarbonyl)-1-o-[(Diisopropylamino)(2-Cyanoethoxy)Phosphino]-3-o-[4,4'-Dimethoxy-4''-(1H,1H,2H,2H-Perfluorodecyl)Trityl]-1,3-Propanediol is a highly specialized phosphoramidite monomer, a critical building block in automated oligonucleotide synthesis. This compound is engineered for the solid-phase synthesis of DNA and RNA sequences, where its unique structure provides exceptional coupling efficiency and stability. It is an essential raw material for research institutions, diagnostic kit manufacturers, and pharmaceutical companies developing advanced therapeutics like antisense oligonucleotides, siRNA, and aptamers.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated solid-phase synthesis of DNA and RNA strands.
• Therapeutic Development: Production of active pharmaceutical ingredients (APIs) for antisense, siRNA, and other nucleic acid-based therapeutics.
• Diagnostic Probes: Manufacture of labeled probes and primers for PCR, qPCR, and next-generation sequencing (NGS) applications.
• Research Reagents: Synthesis of custom oligonucleotides for fundamental biochemical and genetic research.
• Bioconjugation: Facilitating the site-specific modification of oligonucleotides with fluorophores, quenchers, or other functional groups via its reactive sites.
• High-Throughput Synthesis: Suitable for use in array-based and combinatorial synthesis platforms for genomic screening.

Basic Information

Product Name	2,2'-Bis(Ethoxycarbonyl)-1-o-[(Diisopropylamino)(2-Cyanoethoxy)Phosphino]-3-o-[4,4'-Dimethoxy-4''-(1H,1H,2H,2H-Perfluorodecyl)Trityl]-1,3-Propanediol
CAS No.	1027512-47-5
Molecular Formula	C51H66F17N2O10P
Molecular Weight	~1189.0 g/mol
Synonyms	5'-O-(4,4'-Dimethoxy-4''-(1H,1H,2H,2H-Perfluorodecyl)trityl)-2,2-bis(ethoxycarbonyl)-1,3-propanediol-1-[(2-cyanoethoxy)(diisopropylamino)phosphoramidite]; Fluorous-Tagged Phosphoramidite; Fluorous CPG Synthesis Monomer; 5'-Fluorous-MMT Phosphoramidite; F-MMT Phosphoramidite; 1-O-[(Diisopropylamino)(2-cyanoethoxy)phosphino]-3-O-[4,4'-dimethoxy-4''-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trityl]-2,2-bis(ethoxycarbonyl)propane-1,3-diol
EINECS	Contact for details

Quality Control

This high-purity phosphoramidite is manufactured under strict quality control protocols to ensure batch-to-batch consistency and optimal performance in sensitive synthesis applications. Quality is verified by NMR (¹H, ³¹P) and HPLC analysis, with typical purity exceeding 97%. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and moisture content is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dedicated freezer. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to degradation. Allow the sealed vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (NMR)	Conforms to structure (¹H, ³¹P)
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.