Description

tert-Butyl 4-Aminooctahydro-2H-Isoindole-2-Carboxylate is a high-purity, protected amino acid derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive amine group for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and cardiovascular targets.
• Peptidomimetic Synthesis: Used to incorporate constrained, bicyclic amino acid motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Serves as a scaffold for developing enzyme inhibitors, receptor ligands, and other molecular tools for biological research.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for candidate drugs during late-stage development.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological studies in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 4-Aminooctahydro-2H-Isoindole-2-Carboxylate
CAS No.	1027333-18-1
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	4-Amino-octahydro-isoindole-2-carboxylic acid tert-butyl ester; tert-Butyl 4-amino-2,3,3a,4,5,6,7,7a-octahydro-1H-isoindole-2-carboxylate; 2H-Isoindole-2-carboxylic acid, 4-aminooctahydro-, 1,1-dimethylethyl ester; Boc-4-Amino-octahydroisoindole; 4-Amino-octahydroisoindole-2-carboxylic acid tert-butyl ester; (3aS,4S,7aR)-tert-Butyl 4-aminooctahydro-1H-isoindole-2-carboxylate (stereoisomer).
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Aminooctahydro-2H-Isoindole-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.