Description

4-Bromo-1-Phenylsulfonyl-3-Chlorosulfonylindol is a high-value, multi-functionalized indole derivative serving as a critical advanced intermediate in organic synthesis. Its unique structure, featuring both bromo and chlorosulfonyl substituents, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Research: Used to develop new herbicides, fungicides, and insecticides by acting as a core scaffold for structure-activity relationship (SAR) studies.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers, dyes, and organic electronic materials.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to introduce complex aryl/heteroaryl groups.
• Sulfonamide Library Synthesis: The reactive chlorosulfonyl group is ideal for parallel synthesis to create diverse libraries of sulfonamide-containing compounds for high-throughput screening.

Basic Information

Item	Detail
Product Name	4-Bromo-1-Phenylsulfonyl-3-Chlorosulfonylindol
CAS No.	1027069-88-0
Molecular Formula	C14H9BrClNO4S2
Molecular Weight	434.71 g/mol
Synonyms	4-Bromo-1-(phenylsulfonyl)-1H-indole-3-sulfonyl chloride; 1-(Benzenesulfonyl)-4-bromo-1H-indole-3-sulfonyl chloride; 4-Bromo-1H-indole-3-sulfonyl chloride, 1-(phenylsulfonyl)-; 4-Bromo-1-(phenylsulfonyl)indole-3-sulfonyl chloride; 1027069-88-0; 4-Bromo-1-phenylsulfonylindole-3-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Phenylsulfonyl-3-Chlorosulfonylindol is manufactured and tested under a strict quality management system. We ensure the product meets high-purity standards suitable for research and development applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as confirmed by advanced analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.