Description

(E)-3-(4-Chloro-3-Nitrophenyl)-n-[2-(1H-Indol-3-Yl)Ethyl]-2-Propenamide is a specialized, high-purity synthetic intermediate of significant interest in advanced organic synthesis. This compound is valued for its unique molecular architecture, which incorporates both indole and nitro-chlorophenyl moieties, making it a versatile building block for complex molecule construction. It is primarily utilized by research institutions and pharmaceutical development companies engaged in the discovery and synthesis of novel bioactive molecules, including potential kinase inhibitors and other therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting specific enzyme pathways.
• Chemical Biology Probes: Used to develop molecular probes for studying protein-ligand interactions and cellular signaling mechanisms.
• Medicinal Chemistry: Acts as a key scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Organic Synthesis Intermediate: Employed in multi-step synthetic routes to create complex heterocyclic compounds and fine chemicals.
• Bioconjugation Chemistry: The reactive amide and aromatic groups can be utilized for linking molecules in bioconjugate and materials science applications.

Basic Information

Product Name	(E)-3-(4-Chloro-3-Nitrophenyl)-n-[2-(1H-Indol-3-Yl)Ethyl]-2-Propenamide
CAS No.	1025276-57-6
Molecular Formula	C19H16ClN3O3
Molecular Weight	369.80 g/mol
Synonyms	(E)-N-[2-(1H-Indol-3-yl)ethyl]-3-(4-chloro-3-nitrophenyl)prop-2-enamide; 3-(4-Chloro-3-nitrophenyl)-N-[2-(1H-indol-3-yl)ethyl]acrylamide; (E)-3-(4-Chloro-3-nitrophenyl)-N-[2-(1H-indol-3-yl)ethyl]acrylamide; 1025276-57-6; (E)-3-(4-Chloro-3-nitrophenyl)-N-[2-(1H-indol-3-yl)ethyl]-2-propenamide; Acrylamide, 3-(4-chloro-3-nitrophenyl)-N-[2-(1H-indol-3-yl)ethyl]-, (E)-; CHEMBL3185220
EINECS	Contact for details

Quality Control

Our production of (E)-3-(4-Chloro-3-Nitrophenyl)-n-[2-(1H-Indol-3-Yl)Ethyl]-2-Propenamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for research reproducibility. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.