Description

Hydromorphone-D6 is a deuterium-labeled internal standard of the potent opioid analgesic, hydromorphone. This high-purity, isotopically enriched compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors, where precise measurement of hydromorphone levels is required.

Application

• Primary use as an internal standard for the quantification of hydromorphone in biological matrices (e.g., plasma, urine) via LC-MS/MS and GC-MS.
• Metabolic and pharmacokinetic studies to track the absorption, distribution, metabolism, and excretion of hydromorphone.
• Supporting forensic analysis and clinical toxicology for accurate drug level determination in compliance and legal cases.
• Method development and validation in pharmaceutical R&D and bioanalytical laboratories.
• Quality control and assurance testing for hydromorphone-based active pharmaceutical ingredients (APIs) and finished dosage forms.
• Use in research investigating opioid receptor binding and mechanism of action studies.

Basic Information

Product Name	Hydromorphone-D6
CAS No.	1024922-02-8
Molecular Formula	C17H15D6NO3
Molecular Weight	291.37 g/mol
Synonyms	Dihydromorphinone-D6; 4,5α-Epoxy-3-hydroxy-17-methylmorphinan-6-one-D6; (5α)-4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one-D6; 14-Hydroxydihydromorphinone-D6; Deuterated Hydromorphone; Hydromorphone (phenyl-D5, methyl-D); Hydromorphone-d6 (Major)
EINECS	Contact for details

Quality Control

Our Hydromorphone-D6 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by comprehensive analytical data, including HPLC for chemical purity and MS for isotopic enrichment verification. Certificates of Analysis (COA) detailing lot-specific results are provided to guarantee traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.