Description

1-(2H3)Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a deuterated pyrazole boronic ester derivative, a high-value building block in advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise isotopic labeling and robust cross-coupling reactivity. It is primarily utilized in the development of novel pharmaceuticals, agrochemicals, and materials science applications where its deuterium label and protected boronate functionality offer unique advantages.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of deuterated drug candidates for improved metabolic stability and pharmacokinetic profiles.
• Agrochemical Research: Used in creating novel, labeled active ingredients for studying environmental fate and metabolic pathways.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, protected boronate ester reagent for constructing complex biaryl and heterobiaryl structures.
• Isotope Labeling (Deuterium): Essential for preparing internal standards for mass spectrometry (LC-MS/MS) in bioanalytical and diagnostic applications.
• Materials Science: Precursor for synthesizing functional organic molecules used in organic electronics and advanced polymers.
• Chemical Biology Probes: Enables the creation of tagged molecules for studying biological mechanisms and target engagement.

Basic Information

Product Name	1-(2H3)Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1022151-50-3
Molecular Formula	C9H14D3BN2O2
Molecular Weight	195.06 g/mol
Synonyms	1-(Trideuteriomethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(Methyl-d3)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(methyl-d3)-1H-pyrazole; 1-(2H3)Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(Methyl-d3)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; Deuterated Pyrazole Boronic Ester; 1-(CD3)-4-BPin-Pyrazole
EINECS	Contact for details

Quality Control

Our 1-(2H3)Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (D-enrichment), chemical purity, and identity confirmation. We support cGMP compliance for advanced intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.