Description

Risperidone-D4 is a stable isotope-labeled analog of the antipsychotic drug risperidone, where four hydrogen atoms are replaced by deuterium. This compound is an essential internal standard for the precise and accurate quantification of risperidone in biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors, ensuring reliable data for drug metabolism studies, pharmacokinetic profiling, and bioanalytical method validation.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the bioanalysis of risperidone.
• Quantitative analysis in pharmacokinetic and drug metabolism studies to understand absorption, distribution, metabolism, and excretion (ADME).
• Method development and validation in pharmaceutical quality control and research & development (R&D) laboratories.
• Applications in forensic and clinical toxicology for the accurate measurement of risperidone levels in plasma, serum, or urine.
• Use in stable isotope dilution assays to correct for analyte loss during sample preparation and instrument variability.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing validated analytical data.

Basic Information

Product Name	Risperidone-D4
CAS No.	1020719-76-9
Molecular Formula	C23H23D4FN4O2
Molecular Weight	~ 414.50 g/mol
Synonyms	3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one-d4; Risperidone (phenyl-d4); Deuterated Risperidone; Risperidone-d4 Internal Standard; 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-, 9,10,11,12-d4-
EINECS	Contact for details

Quality Control

Our Risperidone-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch undergoes rigorous testing, including HPLC for chemical purity and MS for isotopic purity (D-enrichment). A comprehensive Certificate of Analysis (COA) detailing the specifications and test results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.