Description

Penciclovir-D4 CAS NO 1020719-72-5 is a deuterated analog of the antiviral drug penciclovir, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and quality control of antiviral formulations.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of penciclovir and its prodrug famciclovir in biological matrices (plasma, serum, urine) during pharmacokinetic and bioanalytical studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track the parent drug and metabolites with high specificity.
• Pharmaceutical Quality Control: Ensures assay accuracy and validates analytical methods for penciclovir-containing drug products in compliance with regulatory guidelines (e.g., FDA, ICH).
• Clinical Research: Supports therapeutic drug monitoring and bioequivalence studies for generic antiviral drug development.
• Reference Material: Serves as a certified reference standard for calibrating instruments and qualifying analytical methods in GLP/GMP environments.

Basic Information

Product Name	Penciclovir-D4
CAS No.	1020719-72-5
Molecular Formula	C10H11D4N5O3
Molecular Weight	257.28 g/mol
Synonyms	9-[4-Hydroxy-3-(hydroxymethyl)butyl]-2-amino-1,9-dihydro-6H-purin-6-one-d4; 2-Amino-9-(4-hydroxy-3-hydroxymethylbut-1-yl)-1,9-dihydro-purin-6-one-d4; Penciclovir (D4); Deuterated Penciclovir; Penciclovir Internal Standard; Penciclovir-d4; [2,2,3,3-2H4]-Penciclovir
EINECS	Contact for details

Quality Control

Our Penciclovir-D4 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity (by HPLC), and identification. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific purity or enrichment requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.