Description

2-Methyl-D3-Propionic-3,3,3-D3-Amide is a deuterium-labeled isotopologue of 2-methylpropionamide, a compound of significant interest in advanced research and analytical chemistry. Its core value lies in its utility as a stable isotope-labeled internal standard, enabling precise quantification and metabolic pathway tracing in complex biological and chemical systems. This high-purity compound is essential for researchers and developers in the pharmaceutical, agrochemical, and analytical instrumentation sectors who require uncompromised accuracy in mass spectrometry and NMR studies.

Application

• As a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of 2-methylpropionamide or related metabolites in bioanalytical LC-MS/MS methods.
• For use in pharmacokinetic and drug metabolism studies to track the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• In NMR spectroscopy as a deuterated probe or solvent additive for mechanistic studies and structural analysis.
• As a key chemical reference standard in quality control laboratories for method development and validation.
• For metabolic pathway research in both mammalian and environmental systems, providing insights into biochemical transformations.
• In the synthesis of more complex deuterium-labeled fine chemicals and active pharmaceutical ingredients (APIs) for specialized applications.

Basic Information

Product Name	2-Methyl-D3-Propionic-3,3,3-D3-Amide
CAS No.	1020719-64-5
Molecular Formula	C4H6D3NO
Molecular Weight	90.14 g/mol (for C4H6D3NO)
Synonyms	Isobutyramide-3,3,3-d3; 2-Methylpropanamide-3,3,3-d3; (2H3)Propionamide, 2-methyl-; Deuterated Isobutyramide; Isobutyric-d3 acid amide; 2-Methylpropionamide-d3; Isobutanamide-d3
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is characterized by advanced analytical techniques including NMR, LC-MS, and HPLC to verify identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0% (Chemical Purity)
Isotopic Enrichment	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.