Description

2-Methyl-D3-Propane-3,3,3-D3-Thioamide is a deuterium-labeled isotopologue of 2-methylpropane thioamide, a critical building block for advanced research and development. This compound is specifically designed for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic pathway tracing in complex biological and chemical matrices. It is essential for scientists in pharmaceutical R&D, agrochemical development, and academic research who require high-fidelity analytical tools for pharmacokinetic studies, metabolite identification, and stable isotope labeling experiments.

Application

• Internal Standard for Mass Spectrometry (LC-MS/MS, GC-MS): Provides unmatched accuracy for quantitative bioanalysis in drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Tracing: Used in stable isotope labeling experiments to track the fate of molecules in biological systems.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants.
• Agrochemical Research: Supports environmental fate studies and residue analysis of crop protection agents.
• Chemical Mechanism Elucidation: Serves as a probe in reaction kinetics and mechanistic studies in synthetic chemistry.
• Proteomics and Metabolomics: Enables relative and absolute quantification in high-throughput '-omics' screening platforms.

Basic Information

Product Name	2-Methyl-D3-Propane-3,3,3-D3-Thioamide
CAS No.	1020719-63-4
Molecular Formula	C4H4D3NS
Molecular Weight	104.17 g/mol
Synonyms	2-Methylpropanethioamide-d3; Isobutyrothioamide-d3; 2-Methylpropane-3,3,3-d3-thioamide; 3,3,3-Trideuterio-2-methylpropanethioamide; Isobutyramide-d3, thio-; Deuterated Isobutyrothioamide; (2H3)-Isobutyrothioamide; Isobutyric acid thioamide-d3
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR (1H, 13C) and high-resolution mass spectrometry to confirm deuteration level and chemical identity. A comprehensive Certificate of Analysis (COA) is provided, detailing assay (by HPLC), isotopic enrichment (by MS), and related substance profiles. We support compliance with cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and isotopic purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration Degree)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.