Description

Loratadine-D5 is a stable isotope-labeled analog of the widely used antihistamine, Loratadine. This high-purity compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the accuracy and reliability of pharmacokinetic and metabolism studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development and quality control of antihistamine medications. Our product is supplied to meet the stringent demands of modern analytical chemistry.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application for quantifying Loratadine and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic and Bioequivalence Studies: Enables precise measurement of drug absorption, distribution, metabolism, and excretion (ADME) in clinical trials.
• Drug Metabolism Research: Used to track and quantify metabolic pathways and identify metabolites in in vitro and in vivo studies.
• Pharmaceutical Quality Control: Supports method development and validation for the assay of Loratadine in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Forensic and Toxicology Analysis: Aids in the accurate detection and quantification of Loratadine in forensic investigations.
• Reference Standard for NMR Spectroscopy: Serves as a deuterated reference material in spectroscopic analysis.

Basic Information

Product Name	Loratadine-D5
CAS No.	1020719-57-6
Molecular Formula	C22H18ClD5N2O2
Molecular Weight	382.90 g/mol (for D5 isotopologue)
Synonyms	Loratadine (ethyl-d5); 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl-d5 ester; Claritin-D5; SCH 29851-D5; Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate-d5; Deuterated Loratadine (D5); Loratadine-d5 (ethyl-d5 ester).
EINECS	Contact for details

Quality Control

Our Loratadine-D5 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic purity (D-enrichment), chemical purity, and confirming the absence of unlabeled compound. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.