Description

2-Hydroxyethyl-1,1,2,2-D4 Methanethiosulfonate is a deuterium-labeled isotopologue of a key biochemical reagent used for site-directed spin labeling and protein structure-function studies. This compound matters for researchers requiring high isotopic purity and chemical stability to ensure accurate, reproducible results in advanced spectroscopic and mass spectrometry applications. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotech companies engaged in proteomics, structural biology, and drug discovery.

Application

• Site-Directed Spin Labeling (SDSL) in Electron Paramagnetic Resonance (EPR) spectroscopy for studying protein dynamics and conformational changes.
• Isotopic Labeling for Mass Spectrometry (MS), enabling precise tracking and quantification in proteomic analysis and metabolic studies.
• Structural Biology Research, as a thiol-specific modifying agent for introducing stable isotopic markers into cysteine residues of proteins.
• Bioconjugation and Protein Engineering, facilitating the controlled attachment of probes or other molecules to specific sites on biomolecules.
• NMR Spectroscopy, where deuterium labeling simplifies spectra and provides insights into molecular structure and environment.
• Development of Diagnostic Assays and research tools that rely on highly specific protein modification.

Basic Information

Product Name	2-Hydroxyethyl-1,1,2,2-D4 Methanethiosulfonate
CAS No.	1020719-50-9
Molecular Formula	C₃H₂D₄O₃S₂
Molecular Weight	158.23 g/mol
Synonyms	(2-Hydroxyethyl-d4) methanethiosulfonate; 2-Hydroxyethyl-d4 methanethiosulfonate; 1,1,2,2-Tetradeutero-2-hydroxyethyl methanethiosulfonate; MTSL-d4 reagent; Deuterated MTSL; Deuterated (2-Hydroxyethyl) methanethiosulfonate; S-Methyl-d4 methanethiosulfonate ethanol-d4; Deuterated spin label reagent
EINECS	Contact for details

Quality Control

Our 2-Hydroxyethyl-1,1,2,2-D4 Methanethiosulfonate is produced under controlled conditions to ensure high isotopic and chemical purity, critical for sensitive research applications. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to verify identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. Keep the container in a dry, cool, and well-ventilated place. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.