Description

9-[2-(Diethylphosphonomethoxy)Propyl-D6] Adenine is a high-purity, deuterium-labeled adenine derivative, specifically designed for advanced research and development applications. This compound serves as a critical stable isotope-labeled intermediate, enabling precise metabolic and pharmacokinetic studies in pharmaceutical discovery. It is primarily utilized by researchers and process chemists in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of active pharmaceutical ingredients (APIs) and metabolites in method development and validation.
• Metabolic Tracing Studies: The deuterium (D6) labeling makes it an essential tool for mass spectrometry-based studies, including drug metabolism and pharmacokinetics (DMPK) and absorption, distribution, metabolism, and excretion (ADME) research.
• Internal Standard for Bioanalysis: Provides high accuracy and precision in liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) assays for therapeutic drug monitoring and clinical trials.
• Process Chemistry Intermediate: Acts as a key synthetic building block in the development and scalable production of novel nucleoside analog pharmaceuticals.
• Proteomics & Biochemical Research: Employed in specialized biochemical assays to study enzyme mechanisms and nucleotide-related pathways.

Basic Information

Product Name	9-[2-(Diethylphosphonomethoxy)Propyl-D6] Adenine
CAS No.	1020719-38-3
Molecular Formula	C₁₃H₁₇D₆N₅O₄P
Molecular Weight	Contact for details
Synonyms	9-[2-(Diethylphosphonomethoxy)Propyl-D6]Adenine; PMPA-D6; (R)-9-(2-Phosphonomethoxypropyl)adenine-d6; (R)-PMPA-d6; GS-1278-d6; Adefovir-d6 precursor; Tenofovir-d6 intermediate; Deuterated Adefovir diphosphonate analog
EINECS	Contact for details

Quality Control

Our 9-[2-(Diethylphosphonomethoxy)Propyl-D6] Adenine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to ensure high chemical and isotopic purity suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and deuterium enrichment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.