Description

Carvedilol-D3 is a deuterium-labeled analog of the non-selective β-blocker carvedilol, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolism studies, as it corrects for analyte loss during sample preparation and analysis. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bodies engaged in drug development and bioequivalence testing for cardiovascular therapies.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of carvedilol in biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification & Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• Method Development & Validation: Critical for developing, optimizing, and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Drug-Drug Interaction Studies: Used in assays to investigate the impact of co-administered drugs on carvedilol metabolism and clearance.
• Quality Control in Bioanalytical Labs: Ensures data integrity and reproducibility in routine analysis, supporting GMP and GLP compliance.

Basic Information

Product Name	Carvedilol-D3
CAS No.	1020719-25-8
Molecular Formula	C24H23D3N2O4
Molecular Weight	410.50 g/mol (approximate)
Synonyms	1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d3; (±)-[3H]Carvedilol; Carvedilol (D3); Carvedilol-d3; 1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d3; BM 14190-d3; (RS)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d3; Deuterated Carvedilol
EINECS	Contact for details

Quality Control

Our Carvedilol-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided, supporting compliance with GLP and ISO 17025 standards for research and regulatory work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.