Description

9-(4-Acetoxy-3-Acetoxymethylbutyl)-2-Amino-6-Chloropurine-D4 is a deuterated analog of a key purine nucleoside intermediate, offering a stable isotope-labeled standard for advanced research and development. This compound is essential for ensuring accuracy and reliability in analytical methods, particularly in pharmacokinetic and metabolic studies where precise quantification is critical. It is primarily utilized by pharmaceutical researchers and analytical laboratories specializing in the development of antiviral and anticancer therapeutics.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical deuterated internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and elucidate metabolic pathways of purine-based pharmaceuticals.
• Pharmaceutical Reference Standard: Provides a certified reference material for quality control and method validation in the production of nucleoside analog drugs.
• Biochemical Research: Employed in mechanistic studies involving enzyme inhibition and nucleotide biochemistry due to its modified purine structure.
• Proteomics and Biomarker Discovery: Facilitates accurate mass spectrometry-based proteomic analyses where isotope-labeled compounds are required for relative quantification.

Basic Information

Product Name	9-(4-Acetoxy-3-Acetoxymethylbutyl)-2-Amino-6-Chloropurine-D4
CAS No.	1020718-81-3
Molecular Formula	C15H15D4ClN5O4
Molecular Weight	Contact for details
Synonyms	2-Amino-9-[(4-acetoxy-3-acetoxymethyl)butyl]-6-chloropurine-d4; 6-Chloro-9-(4-acetoxy-3-acetoxymethylbutyl)guanine-d4; 2-Amino-6-chloro-9-(4-acetoxy-3-acetoxymethylbutyl)purine-d4; Deuterated Acyclovir Intermediate-d4; 9-(4-Acetoxy-3-acetoxymethylbutyl)guanine-d4 derivative; [(2-Amino-6-chloro-9H-purin-9-yl)methoxy]ethyl ester-d4 (acetate); Acyclic purine nucleoside analog-d4.
EINECS	Contact for details

Quality Control

Every batch of 9-(4-Acetoxy-3-Acetoxymethylbutyl)-2-Amino-6-Chloropurine-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, verified by advanced analytical techniques including NMR and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and identity is provided with each shipment to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and should be handled under inert conditions when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.