Description

Minoxidil-D10 is a stable isotope-labeled analog of the vasodilator minoxidil, where ten hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolism studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers developing or validating analytical assays for minoxidil and related formulations.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the precise quantification of minoxidil in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to track the absorption, distribution, metabolism, and excretion (ADME) profile of minoxidil.
• Bioanalytical Method Development & Validation: Critical for developing robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Clinical Trial Support: Enables accurate measurement of minoxidil concentration in plasma, serum, or urine samples during clinical research.
• Forensic and Doping Control Analysis: Supports high-confidence detection and quantification of minoxidil in forensic toxicology and anti-doping programs.
• Pharmaceutical Quality Control: Can be utilized in advanced QC laboratories for method verification and impurity profiling.

Basic Information

Product Name	Minoxidil-D10
CAS No.	1020718-66-4
Molecular Formula	C9H5D10N5O
Molecular Weight	215.30 g/mol
Synonyms	6-(1-Piperidinyl)-2,4-pyrimidinediamine-d10; 2,4-Diamino-6-piperidino-pyrimidine-d10; 2,4-Diamino-6-(piperidin-1-yl)pyrimidine-d10; Deuterated Minoxidil (D10); Minoxidil (phenyl-d5, piperidine-d5); Minoxidil-d10; [D10]-Minoxidil
EINECS	Contact for details

Quality Control

Every batch of Minoxidil-D10 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and identity confirmation. Our quality commitment aligns with the standards expected for high-value reference materials in regulated environments, supporting compliance with cGMP and GLP principles.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.