Description

Ethyl 2-Amino-4-[3-(Trifluoromethyl)Phenyl]Thiophene-3-Carboxylate is a high-value, multi-functional heterocyclic building block featuring a thiophene core substituted with an amino group and a trifluoromethylphenyl moiety. This compound is specifically engineered to serve as a critical intermediate in advanced organic synthesis, offering significant versatility for constructing complex molecular architectures. It is primarily sought after by research institutions and industrial R&D departments within the pharmaceutical, agrochemical, and materials science sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for organic electronic materials, such as semiconductors for OLEDs (Organic Light-Emitting Diodes) or OFETs (Organic Field-Effect Transistors).
• Chemical Biology Probes: Employed in the synthesis of fluorescent tags or molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.
• Academic & Industrial R&D: Fundamental building block in medicinal chemistry and synthetic methodology research for exploring new chemical spaces and reaction pathways.

Basic Information

Product Name	Ethyl 2-Amino-4-[3-(Trifluoromethyl)Phenyl]Thiophene-3-Carboxylate
CAS No.	1018830-98-2
Molecular Formula	C14H12F3NO2S
Molecular Weight	315.31 g/mol
Synonyms	Ethyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate; 2-Amino-4-(3-trifluoromethylphenyl)thiophene-3-carboxylic acid ethyl ester; 4-(3-(Trifluoromethyl)phenyl)-2-aminothiophene-3-carboxylic acid ethyl ester; Ethyl α-amino-4-(α,α,α-trifluoro-m-tolyl)thiophene-3-carboxylate; ATFC; 3-Thiophenecarboxylic acid, 2-amino-4-[3-(trifluoromethyl)phenyl]-, ethyl ester; 1018830-98-2
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-4-[3-(Trifluoromethyl)Phenyl]Thiophene-3-Carboxylate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.