Description

1-Benzenesulfony-3-Bromo-5-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid Ethyl Ester is a high-purity, multi-functionalized indole derivative designed for advanced synthetic chemistry. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active ingredients. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate complex halogenated and sulfonylated indole scaffolds into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Research: Used as a building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Chemical Biology Probe: Employed in academic and industrial research to study enzyme inhibition and protein-ligand interactions due to its reactive halogen and sulfonyl groups.
• Material Science: Potential monomer or precursor for creating specialty polymers and advanced organic electronic materials with unique optoelectronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API (Active Pharmaceutical Ingredient) development.

Basic Information

Product Name	1-Benzenesulfony-3-Bromo-5-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid Ethyl Ester
CAS No.	1018450-46-8
Molecular Formula	C17H12BrClFNO4S
Molecular Weight	476.70 g/mol
Synonyms	Ethyl 1-Benzenesulfonyl-3-bromo-5-chloro-4-fluoro-1H-indole-2-carboxylate; 3-Bromo-5-chloro-4-fluoro-1H-indole-2-carboxylic acid ethyl ester, 1-benzenesulfonyl derivative; 1-(Phenylsulfonyl)-3-bromo-5-chloro-4-fluoro-1H-indole-2-carboxylic acid ethyl ester; 1018450-46-8; Benzenesulfonyl-protected bromochlorofluoroindole carboxylate
EINECS	Contact for details

Quality Control

Our 1-Benzenesulfony-3-Bromo-5-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.