Description

1-Boc-(3As,6As)-Octahydropyrrolo[3,4-B]Pyrrole is a high-purity, protected bicyclic amine building block of significant importance in modern organic synthesis. This compound serves as a critical chiral intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality chiral scaffolds to accelerate their R&D pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Asymmetric Catalysis Ligand Precursor: Used to develop novel chiral ligands and organocatalysts for enantioselective transformations.
• Agrochemical Synthesis: Serves as a building block for creating advanced, stereochemically defined active ingredients for crop protection.
• Peptidomimetics & Bioactive Molecule Design: The rigid, nitrogen-rich bicyclic structure is ideal for constructing peptidomimetics and other biologically active compounds.
• Chemical Biology Probe Development: Employed in the synthesis of tool compounds and probes for studying biological pathways and target engagement.
• Material Science Research: Potential precursor for specialty polymers and functional organic materials requiring specific stereochemistry.

Basic Information

Product Name	1-Boc-(3As,6As)-Octahydropyrrolo[3,4-B]Pyrrole
CAS No.	1018443-32-7
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	1-Boc-3a,6a-Octahydropyrrolo[3,4-b]pyrrole; tert-Butyl (3aR,6aR)-Hexahydro-1H-pyrrolo[3,4-b]pyrrole-1-carboxylate; (3aR,6aR)-1-(tert-Butoxycarbonyl)octahydro-1H-pyrrolo[3,4-b]pyrrole; (3aR,6aR)-1-Boc-octahydropyrrolo[3,4-b]pyrrole; 1-N-Boc-(3aR,6aR)-octahydropyrrolo[3,4-b]pyrrole; Bicyclic Boc-Protected Diamine; (3aR,6aR)-Hexahydro-1H-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-(3As,6As)-Octahydropyrrolo[3,4-B]Pyrrole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.