Description

{[2-Methyl-4-(Trifluoromethyl)-2H-Pyrazolo[3,4-B]Pyridin-6-Yl]Thio}Acetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrazolopyridine core and trifluoromethyl group. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for oncology, antiviral, and central nervous system (CNS) drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its privileged heterocyclic structure.
• API Synthesis: Serves as a critical precursor in the multi-step manufacturing process of complex target molecules.
• Biochemical Tool Compound: Employed in biochemical assays to study specific biological pathways and protein interactions.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	{[2-Methyl-4-(Trifluoromethyl)-2H-Pyrazolo[3,4-B]Pyridin-6-Yl]Thio}Acetic Acid
CAS No.	1018046-75-7
Molecular Formula	C11H8F3N3O2S
Molecular Weight	303.26 g/mol
Synonyms	2-({2-Methyl-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-6-yl}thio)acetic acid; 6-[(Carboxymethyl)thio]-2-methyl-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridine; [2-Methyl-4-(trifluoromethyl)pyrazolo[3,4-b]pyridin-6-yl]thioacetic Acid; (2-Methyl-4-trifluoromethyl-2H-pyrazolo[3,4-b]pyridin-6-ylsulfanyl)-acetic acid; CAS 1018046-75-7
EINECS	Contact for details

Quality Control

Our {[2-Methyl-4-(Trifluoromethyl)-2H-Pyrazolo[3,4-B]Pyridin-6-Yl]Thio}Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and pre-clinical development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.