Description

tert-Butyl 3-sulfanylpiperidin-1-carboxylate is a versatile and high-purity chemical building block, specifically a protected piperidine derivative featuring a free thiol group. This compound is critical for advanced organic synthesis, enabling the precise introduction of sulfur-containing moieties into complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) agents, enzyme inhibitors, and receptor modulators.
• Peptide Mimetics & Bioconjugation: The reactive thiol group allows for site-specific modification of peptides, proteins, and other biomolecules, useful in creating drug conjugates and diagnostic probes.
• Ligand Synthesis for Catalysis: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that require a functionalized piperidine scaffold.
• Material Science: Used in the synthesis of monomers and functional polymers where the thiol group can participate in thiol-ene click chemistry for network formation.

Basic Information

Product Name	tert-Butyl 3-sulfanylpiperidin-1-carboxylate
CAS No.	1017798-34-3
Molecular Formula	C10H19NO2S
Molecular Weight	217.33 g/mol
Synonyms	1-Boc-3-mercaptopiperidine; 3-Mercapto-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 3-mercaptopiperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-mercaptopiperidine; 3-Thiolpiperidine-1-carboxylic acid tert-butyl ester; N-Boc-3-mercaptopiperidine; 3-SH-Piperidine-1-carboxylic acid tert-butyl ester; Piperidine-3-thiol, 1-Boc-protected
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-sulfanylpiperidin-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and ensure long-term stability. Keep the container in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.