Description

3-Amino-5-(4-Morpholinylmethyl-D 2 )-2-Oxazolidinone-4,4,5-D 3 is a deuterated isotopologue of a key oxazolidinone derivative, serving as a crucial building block in advanced pharmaceutical research and development. This compound is specifically valued for its role in the synthesis of deuterated drug candidates, where the incorporation of deuterium can significantly alter pharmacokinetic profiles, including metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring precise isotopic labeling for metabolic studies and patent strategies.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: A critical intermediate for creating deuterium-labeled versions of oxazolidinone-based pharmaceuticals.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of molecules within biological systems.
• Isotope Effect Research: Enables investigation of the kinetic isotope effect (KIE) to improve drug efficacy and safety profiles.
• Pharmaceutical Reference Standard: Serves as an analytical standard for quality control and regulatory submissions of deuterated drugs.
• Medicinal Chemistry Research: A versatile scaffold for designing and optimizing new chemical entities with enhanced properties.
• Proteomics and Biomarker Discovery: Potential use as a stable isotope-labeled tag in mass spectrometry-based proteomic analyses.

Basic Information

Item	Details
Product Name	3-Amino-5-(4-Morpholinylmethyl-D 2 )-2-Oxazolidinone-4,4,5-D 3
CAS No.	1017793-94-0
Molecular Formula	C8H12D5N3O3
Molecular Weight	~205.26 g/mol (deuterated)
Synonyms	3-Amino-5-[(4-morpholinylmethyl-2,2-dideuterio)]-2-oxazolidinone-4,4,5-trideuterio; Deuterated Linezolid Intermediate; (4R,5S)-5-[(4-Morpholinylmethyl-D2)]-3-amino-2-oxazolidinone-4,4,5-D3; 3-Amino-5-(morpholin-4-ylmethyl-D2)-1,3-oxazolidin-2-one-4,4,5-D3; Deuterated Oxazolidinone Morpholine Derivative; CAS 1017793-94-0; API Intermediate 1017793-94-0
EINECS	Contact for details

Quality Control

Our 3-Amino-5-(4-Morpholinylmethyl-D 2 )-2-Oxazolidinone-4,4,5-D 3 is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity (by HPLC), isotopic purity (deuterium incorporation by 1H/2H NMR or MS), and identity confirmation. We adhere to cGMP guidelines for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.