Description

6-Carboxy-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole, 2-(6-Carboxy-1H-Indazol-1-Yl)Tetrahydro-2H-Pyran is a high-purity, advanced pharmaceutical intermediate featuring a strategically protected indazole carboxylic acid core. This compound is essential for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on oncology, inflammation, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• API Development: Serves as a protected synthon for constructing the indazole moiety in final active pharmaceutical ingredients.
• Chemical Biology Probes: Employed in the development of labeled compounds and probes for target identification and validation.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and novel heterocyclic chemistry.

Basic Information

Product Name	6-Carboxy-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole, 2-(6-Carboxy-1H-Indazol-1-Yl)Tetrahydro-2H-Pyran
CAS No.	1017792-97-0
Molecular Formula	C14H14N2O4
Molecular Weight	274.27 g/mol
Synonyms	1-(Tetrahydro-2H-pyran-2-yl)-1H-indazole-6-carboxylic acid; 2-(6-Carboxy-1H-indazol-1-yl)tetrahydro-2H-pyran; 1H-Indazole-6-carboxylic acid, 1-(tetrahydro-2H-pyran-2-yl)-; THP-protected indazole-6-carboxylic acid; 1-THP-indazole-6-COOH; 6-Carboxy-1-THP-indazole; CAS 1017792-97-0
EINECS	Contact for details

Quality Control

Our 6-Carboxy-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is stable under these conditions but should be kept away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.