Description

2-Methoxy-3-(Trifluoromethyl)Benzyl Bromide is a versatile and highly functionalized benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of a reactive benzylic bromide handle with electron-donating methoxy and electron-withdrawing trifluoromethyl substituents, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for creating complex target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring the 2-methoxy-3-(trifluoromethyl)benzyl moiety.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for constructing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Building block for advanced polymers, liquid crystals, and organic electronic materials due to its aromatic core and functional groups.
• Cross-Coupling Reactions: Effective electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for biaryl formation.
• Nucleophilic Substitution: The benzylic bromide is highly reactive towards a wide range of nucleophiles, facilitating the introduction of diverse functional groups.

Basic Information

Product Name	2-Methoxy-3-(Trifluoromethyl)Benzyl Bromide
CAS No.	1017778-77-6
Molecular Formula	C9H8BrF3O
Molecular Weight	269.06 g/mol
Synonyms	1-(Bromomethyl)-2-methoxy-3-(trifluoromethyl)benzene; α-Bromo-2-methoxy-α,α,α-trifluoro-m-xylene; 2-Methoxy-α,α,α-trifluoro-m-tolylmethyl Bromide; (2-Methoxy-3-(trifluoromethyl)phenyl)methyl Bromide; 3-(Trifluoromethyl)-2-methoxybenzyl Bromide; 2-Methoxy-3-trifluoromethylbenzyl Bromide; m-Tolyl, 2-methoxy-α,α,α-trifluoro-, bromomethyl deriv.
EINECS	Contact for details

Quality Control

Our 2-Methoxy-3-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.