Description

2-Isopropyl-1-Methyl-D3-5-Nitro-1H-Imidazole is a deuterated isotopologue of a key nitroimidazole derivative, offering a stable, non-radioactive isotopic label for advanced research and development. This compound is essential for applications requiring precise metabolic and pharmacokinetic studies, where tracking molecular pathways is critical. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and manufacturers of high-purity reference standards.

Application

• As a deuterated internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical methods using LC-MS/MS.
• In pharmaceutical research for drug metabolism and pharmacokinetics (DMPK) studies, including absorption, distribution, metabolism, and excretion (ADME) profiling.
• For the synthesis of labeled reference materials and metabolites to ensure regulatory compliance and data integrity in drug development.
• Use in mechanistic studies to investigate biochemical pathways and reaction mechanisms without interference from the kinetic isotope effect.
• As a critical building block in the development of novel diagnostic agents and targeted therapies.

Basic Information

Product Name	2-Isopropyl-1-Methyl-D3-5-Nitro-1H-Imidazole
CAS No.	1015855-83-0
Molecular Formula	C7H8D3N3O2
Molecular Weight	172.20 g/mol
Synonyms	1-Methyl-2-(propan-2-yl)-D3-5-nitro-1H-imidazole; 2-Isopropyl-1-methyl-5-nitroimidazole-d3; 5-Nitro-1-methyl-2-(1-methylethyl)-1H-imidazole-d3; Deuterated Metronidazole Impurity/Intermediate; D3-labeled Nitroimidazole; 1H-Imidazole, 2-(1-methylethyl)-1-methyl-5-nitro-, D3-; (2-Isopropyl-1-methyl-5-nitro-1H-imidazole)-d3
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic techniques, including NMR and Mass Spectrometry, to confirm deuteration level and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere such as nitrogen or argon to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.