Description

4-Hydroxypiperidine-2,2,6,6-D4 is a deuterated derivative of 4-hydroxypiperidine, a valuable building block in synthetic organic chemistry. This isotopically labeled compound is essential for creating internal standards and labeled analogs used in advanced analytical and pharmacological research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Deuterated Internal Standard for LC-MS/MS: Used as a high-purity reference standard in quantitative bioanalytical methods for accurate measurement of parent compounds in biological matrices.
• Metabolic Pathway Tracing: Employed in drug metabolism studies to track the fate of active pharmaceutical ingredients (APIs) and elucidate metabolic pathways.
• Synthesis of Labeled Pharmaceutical Intermediates: Serves as a key precursor for the synthesis of deuterium-labeled drug candidates and active metabolites.
• NMR Spectroscopy Studies: Useful as a tool in nuclear magnetic resonance (NMR) spectroscopy for mechanistic studies and structural analysis.
• Isotope Dilution Mass Spectrometry (IDMS): A critical component in IDMS applications for achieving high-precision and high-accuracy quantification.

Basic Information

Product Name	4-Hydroxypiperidine-2,2,6,6-D4
CAS No.	1014695-51-2
Molecular Formula	C5H5D4NO
Molecular Weight	105.16 g/mol
Synonyms	4-Hydroxypiperidine-d4; Piperidin-4-ol-2,2,6,6-d4; 2,2,6,6-Tetradeutero-4-hydroxypiperidine; 4-Hydroxy-2,2,6,6-tetradeuteropiperidine; 4-Piperidinol-2,2,6,6-d4; 4-Hydroxypiperidine (2,2,6,6-D4); Deuterated 4-Hydroxypiperidine
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing chemical purity, isotopic enrichment (D%), and analytical results from techniques such as NMR, HPLC, and MS. We support compliance with cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.