Description

2-Bromo-3-Formyl-5-Chloro-Thiophene is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both bromo and formyl substituents on a chlorinated thiophene core, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

This specialized thiophene derivative serves as a critical synthon in various high-value chemical syntheses. Key application areas include:

• Pharmaceutical Intermediates: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) agents, antiviral compounds, and kinase inhibitors.
• Agrochemical Actives: Used in the research and development of new generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene scaffold.
• Material Science: Serves as a building block for organic semiconductors, conductive polymers, and non-linear optical (NLO) materials due to the electron-rich thiophene ring.
• Ligand Synthesis: The formyl group allows for the creation of complex chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Research: Employed in methodological studies for cross-coupling reactions (e.g., Suzuki, Stille) and as a model substrate in heterocyclic chemistry.

Basic Information

Item	Details
Product Name	2-Bromo-3-Formyl-5-Chloro-Thiophene
CAS No.	1014644-76-8
Molecular Formula	C5H2BrClOS
Molecular Weight	225.49 g/mol
Synonyms	5-Chloro-2-bromothiophene-3-carboxaldehyde; 5-Chloro-2-bromo-3-thiophenecarboxaldehyde; 2-Bromo-5-chlorothiophene-3-carbaldehyde; 3-Formyl-2-bromo-5-chlorothiophene; 2-Bromo-5-chloro-3-formylthiophene; Thiophene-3-carboxaldehyde, 2-bromo-5-chloro-; (2-Bromo-5-chlorothiophen-3-yl)methanal
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Formyl-5-Chloro-Thiophene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, GC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.