Description

[2-Methyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Phenyl]-Morpholin-4-Yl-Methanone is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions for the synthesis of complex bioactive molecules. Pharmaceutical R&D and fine chemical synthesis teams need it for the development of new drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Medicinal Chemistry Research: Used in the discovery and optimization of novel drug candidates, especially for constructing biaryl and heterobiaryl scaffolds.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts.
• Material Science: Potential building block for organic electronic materials and polymers requiring specific aromatic architectures.
• Agrochemical Synthesis: Intermediate in the development of advanced crop protection agents with complex aromatic backbones.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	[2-Methyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Phenyl]-Morpholin-4-Yl-Methanone
CAS No.	1013643-15-6
Molecular Formula	C18H26BNO4
Molecular Weight	331.22 g/mol
Synonyms	4-Morpholino[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone; 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl morpholin-4-ylmethanone; (4-Morpholinyl)[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone; 1013643-15-6; Boronic acid, B-[4-[(4-morpholinyl)carbonyl]-3-methylphenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our [2-Methyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Phenyl]-Morpholin-4-Yl-Methanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client or regulatory requirements, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.