Description

Methyl 2-(1-(3-Chlorobenzo[B]Thiophene-2-Carbonyl)-3-Oxopiperazin-2-Yl)Acetate is a sophisticated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex pharmacologically active molecules, particularly in medicinal chemistry research and development. Pharmaceutical R&D teams and fine chemical manufacturers need this high-purity intermediate to develop new therapeutic agents, leveraging its unique fused ring system and functional handles for further derivatization.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile piperazinone and benzothiophene scaffold.
• Protease Inhibitor Development: Serves as a core structure or precursor in the development of enzyme inhibitors, given the 3-oxopiperazin-2-yl moiety.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke APIs and advanced intermediates.
• Academic & Institutional Research: Utilized in university and institutional labs for exploring new chemical entities and reaction methodologies.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or bioconjugates for biochemical and diagnostic applications.

Basic Information

Product Name	Methyl 2-(1-(3-Chlorobenzo[B]Thiophene-2-Carbonyl)-3-Oxopiperazin-2-Yl)Acetate
CAS No.	1009520-62-0
Molecular Formula	C17H16ClN3O4S
Molecular Weight	393.84 g/mol
Synonyms	Methyl 2-[1-[(3-chloro-1-benzothiophen-2-yl)carbonyl]-3-oxopiperazin-2-yl]acetate; 2-(1-(3-Chlorobenzo[b]thiophene-2-carbonyl)-3-oxopiperazin-2-yl)acetic acid methyl ester; 3-Chloro-N-(2-(methoxycarbonylmethyl)-5-oxopiperazin-1-yl)benzo[b]thiophene-2-carboxamide; 1009520-62-0; Methyl (2R/S)-2-[1-[(3-chloro-1-benzothiophen-2-yl)carbonyl]-3-oxopiperazin-2-yl]acetate (racemic); 3-Chlorobenzo[b]thiophene-2-carboxylic acid (2-methoxycarbonylmethyl-5-oxo-piperazin-1-yl)-amide
EINECS	Contact for details

Quality Control

Our Methyl 2-(1-(3-Chlorobenzo[B]Thiophene-2-Carbonyl)-3-Oxopiperazin-2-Yl)Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.