Description

2-(2-Chloro-Acetyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific molecular architecture. This compound is critical for the synthesis of complex bioactive molecules, offering researchers and manufacturers a reliable building block for drug discovery and development. It is primarily utilized by the pharmaceutical and biotechnology industries for the research and production of new therapeutic agents.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, particularly those targeting the central nervous system.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• API (Active Pharmaceutical Ingredient) Manufacturing: Employed in the production pathway for specific active pharmaceutical ingredients requiring the tetrahydroisoquinoline scaffold.
• Building Block for Heterocyclic Chemistry: Its reactive functional groups make it valuable for constructing more complex heterocyclic compounds in organic synthesis.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs engaged in custom synthesis and scale-up projects for pharmaceutical clients.

Basic Information

Product Name	2-(2-Chloro-Acetyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid
CAS No.	1009185-81-2
Molecular Formula	C12H12ClNO3
Molecular Weight	253.68 g/mol
Synonyms	2-(2-Chloroacetyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; 1,2,3,4-Tetrahydro-2-(2-chloroacetyl)-3-isoquinolinecarboxylic acid; 3-Carboxy-1,2,3,4-tetrahydroisoquinoline-2-acetyl chloride (deprotected form); THIQ-3-COOH Chloroacetyl derivative; (3-Carboxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloroethanone
EINECS	Contact for details

Quality Control

Our 2-(2-Chloro-Acetyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles suitable for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.