Description

Methyl (3R)-2-(2-Chloroacetyl)-3,4-Dihydro-1H-Isoquinoline-3-Carboxylate is a high-purity chiral building block of significant importance in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel therapeutic agents and functional materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Used as a precursor for constructing complex, stereochemically defined molecular architectures in medicinal chemistry.
• Agrochemical Research: Serves as a building block in the development of novel, high-efficacy pesticides and herbicides.
• Catalyst & Ligand Development: Employed in the research and preparation of novel chiral catalysts and ligands for enantioselective transformations.
• Academic & R&D: Utilized in university and corporate research laboratories for methodological studies and the exploration of new chemical entities.
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals requiring high stereochemical purity.

Basic Information

Item	Details
Product Name	Methyl (3R)-2-(2-Chloroacetyl)-3,4-Dihydro-1H-Isoquinoline-3-Carboxylate
CAS No.	1008996-86-8
Molecular Formula	C13H14ClNO3
Molecular Weight	267.71 g/mol
Synonyms	(3R)-Methyl 2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; (R)-Methyl 2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; Methyl (R)-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; 1008996-86-8; (3R)-2-(2-Chloroacetyl)-3,4-dihydro-1H-isoquinoline-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (3R)-2-(2-Chloroacetyl)-3,4-Dihydro-1H-Isoquinoline-3-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Production adheres to cGMP guidelines where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles, available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.