Description

7-(4-Hydroxybutoxy-4,4-D2)-2(1H)-Quinolinone is a deuterated derivative of a quinolinone-based compound, serving as a crucial advanced intermediate in pharmaceutical research and development. Its primary value lies in its role as a stable isotope-labeled building block, enabling precise metabolic and pharmacokinetic studies for new drug candidates. This high-purity specialty chemical is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing novel therapeutics where deuterium incorporation is used to modify drug metabolism and improve efficacy.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of deuterated active pharmaceutical ingredients (APIs) for clinical development.
• Metabolic Tracer: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and quantify the fate of drug molecules in biological systems.
• Isotope Labeling Agent: Enables the synthesis of deuterium-labeled analogs for use in mass spectrometry and other analytical techniques.
• Medicinal Chemistry Research: Facilitates structure-activity relationship (SAR) studies by providing a modified scaffold with altered physicochemical properties.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development and validation.

Basic Information

Product Name	7-(4-Hydroxybutoxy-4,4-D2)-2(1H)-Quinolinone
CAS No.	1008531-47-2
Molecular Formula	C₁₃H₁₄D₂NO₃
Molecular Weight	236.28 g/mol
Synonyms	7-[(4-Hydroxybutoxy-4,4-d2)]-2(1H)-quinolinone; 2-Hydroxy-7-(4-hydroxybutoxy-4,4-d2)quinoline; 7-(4-Hydroxybutoxy-d2)carbostyril; Deutero-labeled 7-(4-Hydroxybutoxy)quinolin-2(1H)-one; 7-(4-Hydroxybutoxy-4,4-D2)-2-Quinolinol; 7-(4-Hydroxybutoxy-4,4-D2)carbostyril; Deuterated Quinolinone Intermediate
EINECS	Contact for details

Quality Control

Every batch of 7-(4-Hydroxybutoxy-4,4-D2)-2(1H)-Quinolinone is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and isotopic enrichment meet the stringent requirements for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect the material from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.