Description

2-Boc-6-Acetyl-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a ketone functional group. This compound is a critical building block in organic synthesis, enabling the efficient construction of complex nitrogen-containing heterocycles. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex isoquinoline-based drug candidates for therapeutic areas such as CNS disorders and oncology.
• Organic Synthesis Building Block: Used in multi-step synthesis for constructing complex molecular architectures, leveraging its protected amine for selective reactions.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Utilized in universities and R&D labs for methodological studies in heterocyclic and peptide chemistry.

Basic Information

Product Name	2-Boc-6-Acetyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1008518-35-1
Molecular Formula	C₁₇H₂₁NO₃
Molecular Weight	287.35 g/mol
Synonyms	1,2,3,4-Tetrahydro-6-acetylisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 6-acetyl-3,4-dihydro-1H-isoquinoline-2(2H)-carboxylate; 6-Acetyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-Boc-6-acetyl-THIQ; Boc-6-Ac-THIQ; 2-(tert-Butoxycarbonyl)-6-acetyl-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 2-Boc-6-Acetyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material under more stringent quality systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.