Description

n-Boc-6-Iodo-3,4-Dihydroisoquinoline is a high-value, protected heterocyclic building block featuring a versatile iodine substituent, essential for advanced cross-coupling reactions in synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in the development of novel pharmaceutical compounds and agrochemicals. This intermediate is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tetrahydroisoquinoline-based active pharmaceutical ingredients (APIs) for central nervous system (CNS) drugs, oncology therapeutics, and antimicrobial agents.
• Suzuki-Miyaura & Other Cross-Coupling Reactions: The iodine atom serves as an excellent handle for palladium-catalyzed cross-coupling, enabling the introduction of aryl, heteroaryl, and vinyl groups to elaborate the core scaffold.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and plant growth regulators that require the tetrahydroisoquinoline pharmacophore.
• Chemical Biology & Probe Development: Employed in creating molecular probes and tool compounds for studying biological pathways and target validation.
• Material Science Research: Serves as a building block for organic semiconductors, ligands for catalysis, and other functional organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	n-Boc-6-Iodo-3,4-Dihydroisoquinoline
CAS No.	1008517-84-7
Molecular Formula	C₁₄H₁₆INO₂
Molecular Weight	357.19 g/mol
Synonyms	6-Iodo-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 6-iodo-3,4-dihydroisoquinoline-2(1H)-carboxylate; Boc-6-Iodo-THIQ; N-Boc-6-iodo-1,2,3,4-tetrahydroisoquinoline; 2-(tert-Butoxycarbonyl)-6-iodo-1,2,3,4-tetrahydroisoquinoline; 6-Iodo-N-Boc-1,2,3,4-tetrahydroisoquinoline; BOC-6-I-THIQ
EINECS	Contact for details

Quality Control

Our n-Boc-6-Iodo-3,4-Dihydroisoquinoline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with every batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.