Description

2-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a distinct sulfonyl-substituted tetrahydroisoquinoline scaffold. This compound matters as a critical building block for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs), offering a versatile handle for further functionalization. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Protease Inhibitor Development: The carboxylic acid and sulfonyl groups make it a potential intermediate for designing enzyme inhibitors.
• Chemical Biology Probes: Can be utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes.
• Academic Research: Used in university and institutional labs for methodological development and novel heterocyclic chemistry.

Basic Information

Product Name	2-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	1007984-74-8
Molecular Formula	C12H13NO4S
Molecular Weight	267.30 g/mol
Synonyms	2-(Methylsulfonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; 1,2,3,4-Tetrahydro-2-(methylsulfonyl)-3-isoquinolinecarboxylic acid; 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-(methylsulfonyl)-; 2-Methanesulfonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 2-Methylsulfonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; MS-THIQ-3-COOH
EINECS	Contact for details

Quality Control

Our 2-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.