Description

(S)-tert-Butyl 2-(5-Bromo-1H-Imidazol-2-Yl)Pyrrolidine-1-Carboxylate is a high-purity chiral building block of significant interest in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel therapeutics, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for oncology and anti-inflammatory targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel chemical space.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Protease & Kinase Inhibitor Synthesis: The imidazole-pyrrolidine scaffold is valuable for constructing molecules that interact with specific enzyme active sites.
• Asymmetric Synthesis: Utilized in the preparation of enantiomerically pure compounds due to its defined (S)-configuration.
• Chemical Biology: Can be incorporated into molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Detail
Product Name	(S)-tert-Butyl 2-(5-Bromo-1H-Imidazol-2-Yl)Pyrrolidine-1-Carboxylate
CAS No.	1007882-59-8
Molecular Formula	C12H18BrN3O2
Molecular Weight	316.20 g/mol
Synonyms	(S)-1-Boc-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine; (S)-tert-Butyl 2-(5-bromo-1H-imidazol-2-yl)-1-pyrrolidinecarboxylate; 1-(tert-Butoxycarbonyl)-2-(5-bromo-1H-imidazol-2-yl)-(S)-pyrrolidine; (S)-2-(5-Bromo-1H-imidazol-2-yl)-1-(tert-butoxycarbonyl)pyrrolidine; 5-Bromo-2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazole; Boc-5-Bromo-imidazole-(S)-proline derivative
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 2-(5-Bromo-1H-Imidazol-2-Yl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.