Description

Fmoc-Val-Oh-2,3,4,4,4,5,5,5-D8 is a deuterium-labeled derivative of the Fmoc-protected amino acid L-valine, specifically designed for advanced research and development applications. This compound is critical for studies requiring precise isotopic labeling, such as metabolic pathway tracing, pharmacokinetic analysis, and protein structure elucidation using techniques like mass spectrometry and NMR. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies specializing in peptide synthesis and drug discovery.

Application

• Isotope-Labeled Internal Standards for accurate quantification in Liquid Chromatography-Mass Spectrometry (LC-MS) bioanalytical assays.
• Metabolic Pathway Tracing in drug development to study the absorption, distribution, metabolism, and excretion (ADME) of novel therapeutic peptides.
• Deuterated Peptide Synthesis for the production of stable, labeled peptides used in structural biology and biophysical studies.
• NMR Spectroscopy Studies where deuterium labeling reduces signal complexity and allows for detailed conformational analysis of peptides and proteins.
• Proteomics Research as a building block for creating isotopically coded tags or standards in quantitative proteomic workflows.
• Quality Control Reference Material in GMP environments for the validation of analytical methods for peptide-based pharmaceuticals.

Basic Information

Product Name	Fmoc-Val-Oh-2,3,4,4,4,5,5,5-D8
CAS No.	1007834-06-1
Molecular Formula	C₂₀H₁₃D₈NO₄
Molecular Weight	351.42 g/mol (for deuterated form)
Synonyms	Fmoc-L-valine-2,3,4,4,4,5,5,5-d8; N-(9-Fluorenylmethoxycarbonyl)-L-valine-d8; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-methyl-d8-butanoic acid; Fmoc-Val(D8)-OH; Fmoc-L-Val-d8; Deuterated Fmoc-Valine; Fmoc-protected deuterated valine; Nα-Fmoc-L-valine-d8
EINECS	Contact for details

Quality Control

Our Fmoc-Val-Oh-2,3,4,4,4,5,5,5-D8 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, essential for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D%), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to relevant industry guidelines to support research and development under GMP/GLP frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Specific Rotation	[α]²⁰D = -15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.