Description

Terazosin (Piperazine D8) is a deuterated analog of the α-1 adrenergic receptor antagonist Terazosin, specifically labeled on the piperazine ring. This compound is a high-value stable isotope-labeled internal standard critical for ensuring accuracy and reliability in quantitative bioanalytical methods. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and clinical trial analysis for the parent drug.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of Terazosin in biological matrices (plasma, serum, urine).
• Essential for conducting pharmacokinetic (PK) and bioavailability studies with high precision, minimizing matrix effects and ion suppression.
• Critical component in drug metabolism and disposition (DMPK) research to understand the absorption, distribution, metabolism, and excretion (ADME) profile of Terazosin.
• Used in clinical trial analysis to monitor drug concentration levels in patients, ensuring study validity and regulatory compliance.
• Supports forensic and anti-doping analysis where precise quantification of pharmaceutical agents is required.
• Valuable for method development and validation in analytical laboratories to meet FDA, EMA, and ICH guidelines.

Basic Information

Product Name	Terazosin (Piperazine D8)
CAS No.	1006718-20-2
Molecular Formula	C₁₉H₂₇D₈N₅O₄
Molecular Weight	405.56 g/mol (for D8 labeled form)
Synonyms	Terazosin-d8; Terazosin (piperazine-d8); 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-([(tetrahydro-2-furanyl)carbonyl]-d8]piperazine; Deuterated Terazosin; Terazosin Internal Standard; Hytrin-d8 (labeled analog); [D8]-Terazosin; 2-[4-[(2-Furanoyl-d8)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
EINECS	Contact for details

Quality Control

Every batch of Terazosin (Piperazine D8) CAS NO 1006718-20-2 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (¹H, ¹³C), Mass Spectrometry, and HPLC. Certificates of Analysis (COA) are provided with each shipment, detailing purity, isotopic enrichment (D8 content), and solvent residues. Our quality commitment ensures consistency for your most sensitive LC-MS/MS applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant in the container. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity (D8)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.