Description

1-(1,4-Benzodioxan-2-Ylcarbonyl)Piperazine-D8 is a deuterated analog of a key piperazine derivative, featuring eight deuterium atoms strategically incorporated into its molecular structure. This deuteration is critical for enhancing metabolic stability and reducing the rate of hydrogen-deuterium exchange in analytical applications, making it a valuable tool for pharmacokinetic and metabolic studies. It is primarily utilized by research scientists and pharmaceutical developers in the fields of drug discovery, analytical chemistry, and as an internal standard for mass spectrometry.

Application

• Pharmaceutical Research & Development: Serves as a stable isotope-labeled internal standard for the precise quantification of its non-deuterated counterpart in bioanalytical assays using LC-MS/MS.
• Metabolic Studies: Used in drug metabolism and pharmacokinetics (DMPK) research to trace metabolic pathways and study the stability of active pharmaceutical ingredients.
• Chemical Synthesis Intermediate: Acts as a deuterated building block for the synthesis of more complex labeled compounds in medicinal chemistry.
• Analytical Reference Standard: Provides a high-purity reference material for method development and validation in quality control laboratories.
• Isotope Dilution Mass Spectrometry (IDMS): Essential for achieving high accuracy and precision in quantitative analysis, minimizing matrix effects.

Basic Information

Item	Details
Product Name	1-(1,4-Benzodioxan-2-Ylcarbonyl)Piperazine-D8
CAS No.	1006717-20-9
Molecular Formula	C13H8D8N2O3
Molecular Weight	Contact for details
Synonyms	1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine-d8; 1,4-Benzodioxan-2-carboxylic acid, 2-(hexadeuteropiperazinyl)-, (2R)-; Deuterated 1-(1,4-Benzodioxan-2-carbonyl)piperazine; Piperazine-d8, 1-(1,4-benzodioxan-2-ylcarbonyl)-; 1-(2,3-Dihydro-1,4-benzodioxin-2-carbonyl)piperazine-d8; [D8]-1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality protocols to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR and Mass Spectrometry to confirm deuteration level and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.