Description

Maleimide-DOTA is a heterobifunctional chelating agent that combines a maleimide functional group with the macrocyclic chelator DOTA. This molecular architecture is critical for creating stable, site-specific conjugates with thiol-containing biomolecules, enabling the precise attachment of radiometals for diagnostic and therapeutic applications. It is an essential building block for researchers and manufacturers in the fields of radiopharmaceuticals, targeted cancer therapy, and molecular imaging.

Application

• Radiopharmaceutical Development: Conjugation to antibodies, peptides, or other targeting vectors for labeling with diagnostic (e.g., 68Ga, 64Cu) or therapeutic (e.g., 177Lu, 90Y, 225Ac) radiometals.
• Precision Oncology: Synthesis of targeted radioligand therapies (RLTs) and companion diagnostics for cancer treatment.
• Molecular Imaging Probes: Creation of agents for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
• Bioconjugation & Linker Chemistry: Site-specific modification of proteins, enzymes, or nanoparticles via cysteine residues.
• Theranostic Pair Development: Enabling the use of chemically identical agents for both imaging and therapy.
• Research & Development: A key reagent in academic and industrial labs for developing novel diagnostic and therapeutic platforms.

Basic Information

Product Name	Maleimide-DOTA
CAS No.	1006711-90-5
Molecular Formula	C24H36N6O10
Molecular Weight	568.58 g/mol
Synonyms	Maleimido-mono-amide-DOTA; 2,2',2''-(10-(2-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid; 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid-10-maleimide; Maleimide-DOTA tris(t-butyl ester); DOTA-Maleimide; Maleimido-DOTA; p-SCN-Bn-DOTA (related compound, differs in functional group)
EINECS	Contact for details

Quality Control

Our Maleimide-DOTA is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.